Related Experiment Video

Updated: Sep 5, 2025

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
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Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Published on: September 20, 2024

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The E3 ligase Thin controls homeostatic plasticity through neurotransmitter release repression

Martin Baccino-Calace1,2, Katharina Schmidt1, Martin Müller1,2,3

  • 1Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.

Elife
|July 7, 2022
PubMed
Summary

The E3 ubiquitin ligase Thin regulates presynaptic homeostatic plasticity by controlling neurotransmitter release. Thin degrades Dysbindin, linking proteostasis to synaptic function and neurological disorders.

Keywords:
D. melanogastergeneticsgenomicshomeostatic plasticityneuroscienceneurotransmitter releaseproteostasis

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