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Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
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Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
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Updated: Sep 5, 2025

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance
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Insulin resistance in children.

Francesca Mainieri1, Veronica Maria Tagi, Francesco Chiarelli

  • 1Department of Paediatrics, University of Chieti, Chieti, Italy.

Current Opinion in Pediatrics
|July 7, 2022
PubMed
Summary
This summary is machine-generated.

Insulin resistance (IR) in children is a growing global health issue. This review covers IR

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Area of Science:

  • Pediatric Endocrinology
  • Metabolic Health
  • Public Health

Background:

  • Insulin resistance (IR) impairs the body's ability to regulate blood glucose.
  • IR is increasingly recognized as a significant global health concern.
  • Childhood IR is linked to various chronic metabolic diseases.

Purpose of the Study:

  • To provide a comprehensive overview of current knowledge on pediatric IR.
  • To focus on the pathophysiology, measurement, risk factors, effects, screening, and treatment of IR in children.

Main Methods:

  • This is a review article.
  • It synthesizes existing research on pediatric insulin resistance.

Main Results:

  • IR in children is a complex condition with significant health implications.
  • Accurate measurement and identification of risk predictors are crucial for managing IR.
  • Early detection and intervention are key to reducing the incidence of IR and associated metabolic diseases.

Conclusions:

  • Addressing pediatric IR is a critical public health challenge.
  • Further research is needed to refine diagnostic methods and therapeutic strategies.
  • A multi-faceted approach is required for effective screening and treatment of IR in children.