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Quantification of the Potential Impact of Glyphosate-Based Products on Microbiomes
Published on: January 10, 2022
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Development of a method to determine workers' personal exposure levels to glyphosate
Kenta Ishii1,2, Akito Takeuchi1, Osamu Nishinoiri3
1Osaka Occupational Health Service Center, Japan Industrial Safety and Health Association, Osaka, Japan.
Journal of Occupational Health
|July 7, 2022
Summary
A new method accurately measures worker exposure to N-(phosphonomethyl)glycine (glyphosate) in air. This validated technique aids in assessing occupational risks associated with glyphosate exposure.
Area of Science:
- Occupational Health
- Environmental Chemistry
- Analytical Chemistry
Background:
- Glyphosate is a widely used herbicide.
- Accurate assessment of worker exposure is crucial for risk management.
- Existing methods may lack precision or practicality for personal monitoring.
Purpose of the Study:
- To develop and validate a method for determining personal exposure levels to glyphosate.
- To enable accurate risk assessments for workers handling glyphosate.
Main Methods:
- Air sampling using a glass fiber filter cassette.
- Extraction of glyphosate with ultrapure water.
- Derivatization followed by high-performance liquid chromatography with fluorescence detection.
Main Results:
- High overall recovery (101%) and excellent stability over 7 days at 4°C.
- Method limit of quantification achieved at 0.060 μg/sample.
- Excellent reproducibility with relative standard deviations of 1.4%-1.8%.
Conclusions:
- The developed method provides reliable 4-hour personal exposure monitoring for glyphosate.
- This technique is suitable for estimating worker exposure levels within a range of 0.250-500 μg/m³.
