Ultrasmall AgBiSe₂ nanodots for CT/thermal imaging-guided photothermal tumor therapy in the NIR-II biowindow

Stimulus-responsive ternary chalcogenide nanomaterials are regarded as promising 'all-in-one' nanotheranostics agents on account of their tunable band structures and multi-metal intrinsic properties. Herein, ultrasmall AgBiSe₂ nanodots are prepared by a simple thermal injection method. It shows a narrow band gap of 0.91 eV and high absorption coefficient in the NIR-II biowindow, resulting in excellent photothermal performance. Under the irradiation of a 1064 nm laser, AgBiSe₂ can induce the overexpression of intracellular heat shock protein (Hsp70) and cell apoptosis to inhibit the growth of tumor cells. The strong signal from CT/thermal imaging also provides guidance for tumor diagnosis. Importantly, AgBiSe₂ can be rapidly excreted from the body, thus avoiding long term toxicity. This study presents the first biomedical application of AgBiSe₂ nanodots in cancer treatment and extends the development of ternary chalcogenide-based semiconductor nanomedicine.