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Development of delayed thyroid stimulating hormone elevation in small-for-gestational-age infants: is a second
Gahyun Lee1, So Yun Park2, Jae Hyun Park2
1Department of Pediatrics, Keimyung University Dongsan Hospital, Daegu, Korea.
Annals of Pediatric Endocrinology & Metabolism
|July 7, 2022
Summary
Small for gestational age (SGA) infants have a higher risk of delayed thyroid stimulating hormone (dTSH) elevation. This study found SGA is a significant risk factor, suggesting further thyroid screening for these infants.
Area of Science:
- Neonatal endocrinology
- Pediatric endocrinology
Background:
- Small for gestational age (SGA) infants may be at increased risk for certain health complications.
- Delayed thyroid stimulating hormone (dTSH) elevation is a concern in preterm infants, but data on SGA late-preterm infants is limited.
Purpose of the Study:
- To investigate the risk of dTSH elevation in SGA late-preterm infants (34-36 weeks gestation).
- To identify factors associated with dTSH development in SGA infants.
Main Methods:
- Retrospective study including 70 SGA infants and 86 matched controls.
- Initial thyroid function tests were normal; infants were monitored for dTSH elevation.
Main Results:
- SGA infants showed a significantly higher prevalence of dTSH elevation (15.7% vs. 3.5%).
- dTSH development was associated with SGA, dopamine, and furosemide treatment.
- Logistic regression confirmed SGA as a significant risk factor (OR, 23.2; P=0.008).
Conclusions:
- SGA infants are at increased risk for dTSH.
- Consider a second thyroid screening test for SGA infants around 1 month of age.
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