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Updated: Sep 5, 2025

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
Published on: June 23, 2023
Chlordiazepoxide-induced delirium in a patient undergoing alcohol withdrawal: a case report
Melissa A Arabadjief1, Omar H Elsayed1, Sabina Bashir1
1Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, USA.
Background:
Ethanol dependence is associated with a discontinuation withdrawal delirium. Chlordiazepoxide is frequently successfully used in its treatment.
Case Presentation:
A 27-year-old, Caucasian female with ethanol dependence who had objective symptoms of withdrawal experienced worsening of her delirium after administration of chlordiazepoxide, but improved with lorazepam and cleared with discontinuation of benzodiazepine administration.
Conclusions:
Worsening of delirium appears to be related to the specific use of chlordiazepoxide, but the mechanism of this effect is not clear. While this case does not alter the standard care of ethanol dependence, it does alert clinicians that our treatment approach may not be fully benign.
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