Related Experiment Video

Updated: Sep 5, 2025

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
10:51

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

12.9K

Nuclear Receptor RORα/γ: Exciting Modulators in Metabolic Syndrome and Related Disorders

Haotian Gu1, Ping Hu1, Yahui Zhao1

  • 1College of Animal Science and Technology, Yangzhou University, Yangzhou, China.

Frontiers in Nutrition
|July 8, 2022
PubMed

Insights

Metabolic syndromes (MetS) are linked to impaired lipid metabolism. Nuclear receptors RORα and RORγ show potential for developing new MetS therapeutics by regulating lipid metabolism genes.

Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Molecular Biology

Background:

  • Metabolic syndromes (MetS) are prevalent chronic diseases increasing risks for type 2 diabetes, heart disease, and stroke.
  • The exact pathogenesis of MetS remains unclear, with limited effective and specific therapeutic drugs available.
  • Impaired lipid metabolism is closely associated with MetS development, suggesting gene modulation as a therapeutic strategy.

Purpose of the Study:

  • To review the latest research on the roles of retinoic acid's receptor-related orphan receptors (RORs), specifically RORα and RORγ, in lipid metabolism.
  • To explore the involvement of RORα and RORγ in the pathogenesis of MetS and related metabolic disorders.
  • To highlight the potential of targeting RORs for future therapeutic applications in managing MetS.

Main Methods:

  • Literature review of recent studies on nuclear receptors (NRs) and their function in lipid metabolism.
  • Analysis of research focusing on RORα and RORγ gene regulation in the context of metabolic disorders.
  • Synthesis of findings related to the therapeutic potential of modulating RORs for MetS.

Main Results:

  • Nuclear receptors, including RORα and RORγ, play crucial roles in regulating genes involved in lipid metabolism.
  • These receptors are implicated in the development and progression of MetS and associated conditions.
  • Evidence suggests that modulating ROR activity can impact lipid metabolism pathways relevant to MetS.

Conclusions:

  • RORα and RORγ are key regulators of lipid metabolism and are involved in MetS pathogenesis.
  • Targeting these nuclear receptors presents a promising avenue for developing novel therapeutics for metabolic syndromes.
  • Further research into RORs could lead to clinically effective treatments for insulin resistance, obesity, and fatty liver disease.
Keywords:
RORα/γinsulin resistancelipidsmetabolic syndromessterols

More Related Videos

Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells07:22

Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells

Published on: March 28, 2013

38.9K
Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots08:30

Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots

Published on: June 2, 2015

9.4K

Related Concept Videos

Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
1.6K
Regulation of Metabolism01:19

Regulation of Metabolism

Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
9.8K
Regulation of Nuclear Protein Sorting01:45

Regulation of Nuclear Protein Sorting

Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
2.4K
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
7.5K
Signal Transduction: Overview01:26

Signal Transduction: Overview

Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
9.1K
Global Regulatory Systems01:28

Global Regulatory Systems

Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
69