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Solitary primary pulmonary synovial sarcoma: A case report
Wei-Wei He1, Zhi-Xin Huang1, Wen-Jing Wang1
1Department of Respiratory and Critical Care Medicine, Nanjing Yimin Hospital, Nanjing 210000, Jiangsu Province, China.
World Journal of Clinical Cases
|July 8, 2022
Summary
Primary pulmonary synovial sarcoma (PPSS) is a rare cancer. Diagnosis involves imaging like PET-CT, histology, and FISH testing. Surgical resection improves outcomes for solitary PPSS cases.
Area of Science:
- Oncology
- Pathology
Background:
- Synovial sarcoma (SS) is a rare and aggressive soft tissue sarcoma.
- Primary pulmonary synovial sarcoma (PPSS) is exceptionally rare.
Observation:
- A 33-year-old male presented with cough and hemoptysis, showing a two-year history of lung shadows.
- Positron emission tomography-computed tomography (PET-CT) identified a solitary right upper lobe lung mass with elevated uptake.
- Histopathological examination revealed spindle-shaped malignant cells, positive for CD99 and BCL-2.
Findings:
- Fluorescence in situ hybridization (FISH) confirmed the synovial sarcoma translocation.
- The case highlights the diagnostic challenges of PPSS, often misdiagnosed as other pulmonary diseases.
Implications:
- PET-CT, histology, and FISH are crucial for differentiating PPSS.
- Surgical resection is the recommended treatment for solitary PPSS, improving patient prognosis.
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