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Effect of Post-nasal Drip on Overnight-cough Frequency and Cough Pattern in Children with Asthma

Kota Hirai1, Chinami Kaiga, Tomofumi Otomo

  • 1Department of Pediatrics, Tokai University School of Medicine, Department of Pediatrics, Tokai University Hachioji Hospital, 1838 Ishikawa-machi, Hachioji, Tokyo 192-0032, Japan. hirai@is.icc.u-tokai.ac.jp.

The Tokai Journal of Experimental and Clinical Medicine
|July 8, 2022
PubMed

Insights

Post-nasal drip (PND) significantly increases nighttime coughs in children with atopic asthma and allergic rhinitis. However, the characteristic cough pattern remains consistent, suggesting shared allergic inflammation pathways.

Area of Science:

  • Pediatric Allergy and Immunology
  • Respiratory Medicine
  • Otolaryngology

Background:

  • Post-nasal drip (PND) is a suspected cause of cough in children, but the direct relationship remains unclear.
  • Asthma and allergic rhinitis frequently coexist in children, complicating the diagnosis and management of cough.

Purpose of the Study:

  • To investigate the association between post-nasal drip (PND) and overnight cough characteristics in children with atopic asthma during acute exacerbations.
  • To determine if PND influences the frequency or pattern of nocturnal coughing in this pediatric population.

Main Methods:

  • A comparative study involving children with atopic asthma and allergic rhinitis during acute exacerbations.
  • Two groups were analyzed: those with PND (n=8) and those without PND (n=27), using a cough monitor to assess overnight cough frequency and pattern.

Main Results:

  • Children with PND experienced a significantly higher total number of overnight coughs compared to those without PND (P < 0.05).
  • The pattern of overnight coughing, characterized by increased frequency at sleep onset and early morning, was similar in both groups.

Conclusions:

  • Post-nasal drip (PND) appears to be a significant factor contributing to increased nighttime cough frequency in children with atopic asthma and allergic rhinitis.
  • The consistent nocturnal cough pattern in both groups suggests that underlying allergic inflammation of the upper and lower airways is a primary driver of this specific cough characteristic.
Abstract

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