Related Experiment Video

Updated: Sep 5, 2025

Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection
04:11

Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection

Published on: December 15, 2023

3.7K

Association of hepatitis C virus infection status and genotype with kidney disease risk: A population-based

Yi-Chia Chen1, Hung-Wei Wang2, Yun-Ting Huang3

  • 1Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.

Plos One
|July 8, 2022
PubMed

Insights

Hepatitis C virus (HCV) infection, both chronic and resolved, increases kidney disease risk. HCV genotype 1 is particularly linked to a higher risk compared to other genotypes.

Area of Science:

  • Nephrology
  • Hepatology
  • Infectious Diseases

Background:

  • Kidney disease risk in resolved hepatitis C virus (HCV) infection is unclear.
  • The influence of specific HCV genotypes on kidney disease risk requires further investigation.

Purpose of the Study:

  • To examine the association between HCV infection status (chronic vs. resolved) and kidney disease risk.
  • To investigate the impact of different HCV genotypes on kidney disease prevalence.

Main Methods:

  • A population-based cross-sectional study using US National Health and Nutrition Examination Survey data (1999-2018).
  • HCV infection defined by seropositivity and RNA detection; kidney disease by estimated GFR and albuminuria.
  • HCV genotypes categorized into 1, 2, and others.

Main Results:

  • Individuals with resolved (14.8%) or chronic (20.1%) HCV infection had higher kidney disease prevalence than those without HCV (uninfected: 14.8%).
  • Adjusted analyses revealed increased kidney disease risk for both resolved (aOR: 1.40) and chronic (aOR: 1.26) HCV infection.
  • HCV genotype 1 infection showed a significantly higher kidney disease risk (aOR: 1.41) compared to no HCV infection, and a 2-fold higher risk (aOR: 2.20) compared to non-genotype 1 HCV.

Conclusions:

  • Both resolved and chronic hepatitis C virus infection are linked to elevated kidney disease risk.
  • Hepatitis C virus genotype 1 infection poses a particularly significant risk for kidney disease development.
Abstract

More Related Videos

A Protocol for Analyzing Hepatitis C Virus Replication13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

24.3K
A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks10:28

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

9.8K

Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
80
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
64
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
56
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
52
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
76
Hepatic Drug Excretion: Influencing Factors01:16

Hepatic Drug Excretion: Influencing Factors

The biliary system of the liver, crucial for bile secretion and drug excretion, comprises intrahepatic bile ducts that merge to form the common hepatic duct. This duct, carrying hepatic bile, combines with the cystic duct, draining the gallbladder and forming the common bile duct, which empties into the duodenum. Bile, produced by hepatic cells lining the bile canaliculi, is composed primarily of water, bile salts, pigments, electrolytes, and lesser amounts of cholesterol and fatty acids. Bile...
211