Pleural and transpulmonary pressures to tailor protective ventilation in children

This review aims to: (1) describe the rationale of pleural (P_PL) and transpulmonary (P_L) pressure measurements in children during mechanical ventilation (MV); (2) discuss its usefulness and limitations as a guide for protective MV; (3) propose future directions for paediatric research. We conducted a scoping review on P_L in critically ill children using PubMed and Embase search engines. We included peer-reviewed studies using oesophageal (P_ES) and P_L measurements in the paediatric intensive care unit (PICU) published until September 2021, and excluded studies in neonates and patients treated with non-invasive ventilation. P_L corresponds to the difference between airway pressure and P_PL Oesophageal manometry allows measurement of P_ES, a good surrogate of P_PL, to estimate P_L directly at the bedside. Lung stress is the P_L, while strain corresponds to the lung deformation induced by the changing volume during insufflation. Lung stress and strain are the main determinants of MV-related injuries with P_L and P_PL being key components. P_L-targeted therapies allow tailoring of MV: (1) Positive end-expiratory pressure (PEEP) titration based on end-expiratory P_L (direct measurement) may be used to avoid lung collapse in the lung surrounding the oesophagus. The clinical benefit of such strategy has not been demonstrated yet. This approach should consider the degree of recruitable lung, and may be limited to patients in which PEEP is set to achieve an end-expiratory P_L value close to zero; (2) Protective ventilation based on end-inspiratory P_L (derived from the ratio of lung and respiratory system elastances), might be used to limit overdistention and volutrauma by targeting lung stress values < 20-25 cmH₂O; (3) P_PL may be set to target a physiological respiratory effort in order to avoid both self-induced lung injury and ventilator-induced diaphragm dysfunction; (4) P_PL or P_L measurements may contribute to a better understanding of cardiopulmonary interactions. The growing cardiorespiratory system makes children theoretically more susceptible to atelectrauma, myotrauma and right ventricle failure. In children with acute respiratory distress, P_PL and P_L measurements may help to characterise how changes in PEEP affect P_PL and potentially haemodynamics. In the PICU, P_PL measurement to estimate respiratory effort is useful during weaning and ventilator liberation. Finally, the use of P_PL tracings may improve the detection of patient ventilator asynchronies, which are frequent in children. Despite these numerous theoritcal benefits in children, P_ES measurement is rarely performed in routine paediatric practice. While the lack of robust clincal data partially explains this observation, important limitations of the existing methods to estimate P_PL in children, such as their invasiveness and technical limitations, associated with the lack of reference values for lung and chest wall elastances may also play a role. P_PL and P_L monitoring have numerous potential clinical applications in the PICU to tailor protective MV, but its usefulness is counterbalanced by technical limitations. Paediatric evidence seems currently too weak to consider oesophageal manometry as a routine respiratory monitoring. The development and validation of a noninvasive estimation of P_L and multimodal respiratory monitoring may be worth to be evaluated in the future.