Related Experiment Video

Updated: Sep 5, 2025

Measuring Global Cellular Matrix Metalloproteinase and Metabolic Activity in 3D Hydrogels
07:39

Measuring Global Cellular Matrix Metalloproteinase and Metabolic Activity in 3D Hydrogels

Published on: January 22, 2019

7.5K

Regulation and Function of Matrix Metalloproteinase-13 in Cancer Progression and Metastasis

Shun Li1, David Mark Pritchard2, Lu-Gang Yu1

  • 1Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 3BX, UK.

Cancers
|July 9, 2022
PubMed

Insights

Matrix metalloproteinase-13 (MMP-13) is an enzyme that aids cancer progression and metastasis. This review details MMP-13

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Matrix metalloproteinase-13 (MMP-13) is an endopeptidase in the MMPs family.
  • Normally produced in low amounts, MMP-13 expression increases in various cancers.

Purpose of the Study:

  • To review the regulation of MMP-13 expression and secretion.
  • To discuss MMP-13's roles in cancer progression and metastasis.

Main Methods:

  • Literature review of scientific articles on MMP-13.
  • Analysis of MMP-13's enzymatic activity and extracellular matrix interactions.

Main Results:

  • MMP-13 cleaves collagens and other extracellular matrix proteins.
  • ECM remodeling by MMP-13 facilitates tumor cell growth, invasion, and angiogenesis.

Conclusions:

  • MMP-13 is a key enzyme in cancer progression and metastasis.
  • Understanding MMP-13 regulation and actions is crucial for developing cancer therapies.
Keywords:
MMP-13angiogenesiscancer invasionmetastasistumour growth

More Related Videos

A Label-Free Segmentation Approach for Intravital Imaging of Mammary Tumor Microenvironment10:39

A Label-Free Segmentation Approach for Intravital Imaging of Mammary Tumor Microenvironment

Published on: May 24, 2022

2.4K
CAM-Delam Assay to Score Metastatic Properties by Quantifying Delamination and Invasion Capacity of Cancer Cells12:14

CAM-Delam Assay to Score Metastatic Properties by Quantifying Delamination and Invasion Capacity of Cancer Cells

Published on: June 2, 2022

2.7K

Related Concept Videos

Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
2.5K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.9K
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.7K
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.8K
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
2.4K
The Extracellular Matrix01:29

The Extracellular Matrix

Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
9.4K