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Enzymatic Isolation of Skeletal Muscle Interstitial Extracellular Vesicles
Published on: February 7, 2025
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Muscle and Adipose Tissue Communicate with Extracellular Vesicles
1CarMeN Laboratory, INSERM 1060/INRAE 1397, Lyon-Sud Faculty of Medicine, LYON 1 University, 69301 Pierre Bénite, France.
International Journal of Molecular Sciences
|July 9, 2022
Summary
Muscle and fat tissues communicate via extracellular vesicles (EVs), nanovesicles carrying signals that influence tissue homeostasis. This intercellular communication is vital for understanding metabolic and cardiovascular diseases.
Area of Science:
- Endocrinology
- Cell Biology
- Physiology
Background:
- Muscle and adipose tissue are metabolically active endocrine organs.
- These tissues interact closely, influencing tissue homeostasis in health and disease.
- Understanding muscle-fat crosstalk is crucial for metabolic and cardiovascular research.
Purpose of the Study:
- To review current knowledge on extracellular vesicles (EVs) in muscle-adipose tissue communication.
- To highlight the role of EVs in modulating recipient cell phenotype and homeostasis.
- To discuss the impact of this communication on metabolic and cardiovascular diseases.
Main Methods:
- Literature review of studies investigating EVs in muscle-adipose tissue crosstalk.
- Analysis of research on the content and function of lipid-derived nanovesicles.
- Synthesis of findings related to intercellular signaling in metabolic health.
Main Results:
- Adipose tissue and muscle release EVs containing signaling molecules.
- EVs mediate communication between these tissues, affecting cellular phenotype and homeostasis.
- This communication pathway is increasingly recognized for its role in disease.
Conclusions:
- Extracellular vesicles (EVs) represent a novel mechanism for muscle-fat communication.
- EV-mediated signaling has revolutionized the understanding of metabolic and cardiovascular diseases.
- Further research into EVs is essential for therapeutic advancements.
Keywords:
adipocytesadipose tissueexosomesextracellular vesiclesmicroparticlesmicrovesiclesmusclestem cellsMore Related Videos
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