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Updated: Sep 5, 2025

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer
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Can Cisplatin Therapy Be Improved? Pathways That Can Be Targeted.

Reem Ali1, Mustapha Aouida1, Abdallah Alhaj Sulaiman1

  • 1Division of Biological and Biomedical Sciences, College of Health and Life Sciences, Hamad Bin Khalifa University, Education City, Qatar Foundation, Doha P.O. Box 34110, Qatar.

International Journal of Molecular Sciences
|July 9, 2022
PubMed
Summary

Cisplatin is a key chemotherapy drug, but tumors develop resistance through DNA repair or tolerance. Understanding these mechanisms and patient genetics is crucial for improving cisplatin efficacy and overcoming resistance.

Keywords:
DNA repaircisplatincisplatin resistanceplatinum sensitisation

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Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Cisplatin (cis-diamminedichloroplatinum (II)) is a cornerstone chemotherapy agent effective against various cancers.
  • Its cytotoxic effect stems from inducing DNA crosslinks, but tumor resistance and nephrotoxicity pose significant challenges.

Purpose of the Study:

  • To review biological processes contributing to cisplatin resistance.
  • To highlight strategies for modulating resistance mechanisms and enhancing drug efficacy.
  • To explore the role of uptake transporters in platinum-based therapy.

Main Methods:

  • Literature review of preclinical and clinical studies on cisplatin resistance.
  • Analysis of molecular and genetic factors influencing treatment response.
  • Discussion of biological pathways involved in DNA repair and tolerance.

Main Results:

  • Tumor cells develop resistance via DNA lesion repair or translesion DNA synthesis.
  • Cisplatin-associated nephrotoxicity limits therapeutic application.
  • No definitive solutions currently exist to overcome resistance comprehensively.

Conclusions:

  • Comprehensive molecular and genetic profiling is needed to identify patients benefiting from cisplatin.
  • Combining cisplatin with targeted therapies may balance tumor toxicity and resistance mechanisms.
  • Modulating biological processes and understanding transporter roles can improve cisplatin efficacy.