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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
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LncRNA-Mediated Adipogenesis in Different Adipocytes.

Peiwen Zhang1,2, Shuang Wu1,2, Yuxu He1,2

  • 1College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.

International Journal of Molecular Sciences
|July 9, 2022
PubMed
Summary

Long-chain noncoding RNAs (lncRNAs) regulate gene expression and are crucial in adipogenesis. This review explores lncRNA functions in white and brown fat development and their roles in metabolic health.

Keywords:
adipose tissuebeige fatbrown fatectopic fatlong noncoding RNA

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Area of Science:

  • Molecular Biology
  • Genetics
  • Endocrinology

Background:

  • Long-chain noncoding RNAs (lncRNAs) are key regulators of gene expression across eukaryotes.
  • Adipose tissue, particularly white adipose tissue, plays a critical role in mammalian metabolism, with its excessive accumulation linked to metabolic diseases.
  • Brown and beige adipose tissues are distinct for their energy-dissipating thermogenic functions.

Purpose of the Study:

  • To review the classification of lncRNAs based on their transcriptional locations.
  • To discuss the involvement of lncRNAs in the adipogenesis of white, brown, and beige adipose tissues.
  • To explore the diverse molecular functions of lncRNAs in regulating gene expression and adipogenesis.

Main Methods:

  • Literature review of current research on lncRNAs and adipogenesis.
  • Classification of lncRNAs by transcriptional origin.
  • Analysis of lncRNA functions, including roles as decoy molecules and in RNA-protein complexes.

Main Results:

  • lncRNAs regulate gene expression at epigenetic, transcriptional, and post-transcriptional levels.
  • Specific lncRNAs are implicated in the differentiation and function of white, brown, and beige adipocytes.
  • lncRNAs function through various mechanisms, including competing with microRNAs and modulating chromatin structure.

Conclusions:

  • lncRNAs are critical regulators of adipogenesis and adipose tissue function.
  • Understanding lncRNA mechanisms provides insights into metabolic disease pathogenesis.
  • Further investigation into lncRNAs offers potential therapeutic targets for metabolic disorders.