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Related Experiment Video

Updated: Sep 5, 2025

Preparation and 3D Tracking of Catalytic Swimming Devices
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Nanoswimmers Based on Capped Janus Nanospheres.

Petteri Piskunen1, Martina Huusela1, Veikko Linko1,2

  • 1Biohybrid Materials, Department of Bioproducts and Biosystems, Aalto University, P.O. Box 16100, 00076 Aalto, Finland.

Materials (Basel, Switzerland)
|July 9, 2022
PubMed
Summary

Functional Janus nanospheres act as artificial nanoswimmers, enabling precise control for targeted drug delivery systems (TDDSs). These synthetic nanoparticles offer promising advancements in controlled drug treatments and biomedical applications.

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Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Materials Science

Background:

  • Nanoswimmers are synthetic nanoscale machines that convert ambient energy into directed motion, mimicking natural microorganisms like bacteria.
  • Artificial nanoswimmers, including hybrid and non-hybrid types, are being developed for various applications, notably in medicine.

Purpose of the Study:

  • This review focuses on functional, capped Janus nanospheres as a specific class of nanoswimmers.
  • The study aims to discuss their subclasses, properties, and implementations, particularly for biomedical uses.

Main Methods:

  • The review synthesizes information on fabrication and synthesis methods for nanoswimmers.
  • It highlights diverse compositions and particle types suitable for biomedical applications.
Keywords:
Janus particlesbiohybridsbiomedicinenanofabricationnanospheresnanoswimmerstargeted delivery

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Main Results:

  • Recent studies demonstrate successful in vitro drug delivery using Janus-particle-based targeted drug delivery systems (TDDSs).
  • These systems show temporal and spatial control over drug release.

Conclusions:

  • Janus nanospheres represent a promising platform for developing advanced nanoswimmers.
  • This review provides an introductory overview to enhance understanding of nanoparticle behavior in biological environments for future TDDS development.