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Updated: Sep 5, 2025

The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia
Published on: November 19, 2008
Nutrition and Immunity in Perinatal Hypoxic-Ischemic Injury
Hema Gandecha1,2, Avineet Kaur1,2, Ranveer Sanghera1,2
1Department of Neonatology, University Hospitals Leicester NHS Trust, Leicester LE1 5WW, UK.
Abstract:
Perinatal hypoxia ischaemia (PHI), acute and chronic, may be associated with considerable adverse outcomes in the foetus and neonate. The molecular and cellular mechanisms of injury and repair associated with PHI in the perinate are not completely understood. Increasing evidence is mounting for the role of nutrients and bioactive food components in immune development, function and repair in PHI. In this review, we explore current concepts around the neonatal immune response to PHI with a specific emphasis on the impact of nutrition in the mother, foetus and neonate.
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