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Evaluation of Blood Coagulation by Optical Vortex Tracking.
Jiaxing Gong1,2, Yaowen Zhang1, Hui Zhang1
1College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Sensors (Basel, Switzerland)
|July 9, 2022
Summary
Optical vortex dynamics offer a rapid, non-contact method for monitoring blood coagulation in real-time. This technique correlates well with traditional thromboelastography, showing promise for point-of-care diagnostics.
Area of Science:
- Biophysics
- Optical Physics
- Hematology
Background:
- Blood coagulation is a complex process vital for hemostasis.
- Real-time monitoring of coagulation is crucial for clinical applications like transfusion and trauma management.
- Current methods may lack speed, non-contact capabilities, or point-of-care suitability.
Purpose of the Study:
- To develop and validate a novel optical vortex dynamics method for rapid, non-contact monitoring of blood coagulation.
- To assess the correlation between optical vortex dynamics and traditional thromboelastography (TEG) parameters.
- To demonstrate the applicability of the method for measuring viscoelasticity in complex fluids.
Main Methods:
- Utilized optical vortex dynamics to track stochastic motion in speckles reflected from blood samples.
- Analyzed the mean square displacement (MSD) of optical vortices over time during coagulation.
- Compared coagulation parameters (reaction time, activated clotting time) derived from optical vortex analysis with TEG measurements.
Main Results:
- The mean square displacement (MSD) of optical vortices increased nonlinearly with time lag, mirroring viscoelastic changes during coagulation.
- MSD curves showed similarity to thromboelastography tracings.
- Optical vortex-derived coagulation parameters closely correlated with TEG-acquired parameters.
Conclusions:
- The optical vortex method is feasible for rapid, non-contact monitoring of blood coagulation at the point of care.
- This technique shows potential for real-time assessment of hemostasis and viscoelasticity in complex fluids.
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