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Age-related changes in diffuse optical tomography sensitivity profiles from childhood to adulthood
1University of South Carolina, Department of Psychology, Columbia, South Carolina, United States.
Journal of Biomedical Optics
|July 10, 2022
Summary
Diffuse optical tomography (DOT) sensitivity profiles change with age. Children show distinct profiles compared to adults, impacting brain imaging accuracy.
Area of Science:
- Neuroimaging
- Biomedical Optics
- Developmental Neuroscience
Background:
- Diffuse optical tomography (DOT) uses near-infrared light to measure brain hemoglobin changes.
- Accurate anatomical interpretation of DOT signals requires understanding DOT sensitivity to the cortex.
- Existing knowledge on DOT sensitivity profiles lacks detail across childhood and adulthood.
Purpose of the Study:
- To investigate age-related differences in DOT sensitivity profiles.
- To analyze DOT sensitivity across a developmental spectrum from 2 to 34 years.
- To provide age-specific DOT sensitivity data for improved brain imaging.
Main Methods:
- Simulated photon migration using existing methods.
- Computed DOT sensitivity for source-detector channels.
- Utilized age-appropriate, realistic head models for simulations.
Main Results:
- DOT sensitivity profiles vary systematically with source-detector distance across all ages.
- Children exhibit distinct DOT sensitivity profiles compared to adults.
- Differences in DOT sensitivity are more pronounced at larger separation distances.
Conclusions:
- Age-specific DOT sensitivity profiles are crucial for accurate brain imaging.
- Using age-appropriate head models enhances anatomical guidance for DOT data.
- Inaccurate head models negatively impact image reconstruction accuracy, especially in children.
