Predictive Value of Geriatric Nutritional Risk Index in Patients With Lower Extremity Peripheral Artery Disease: A...

Area of Science:

• Cardiology
• Geriatrics
• Nutritional Science

Background:

• Conflicting data exists on the Geriatric Nutritional Risk Index (GNRI) for predicting adverse outcomes in peripheral artery disease (PAD).
• Lower extremity PAD patients face significant risks, making accurate prognostic tools crucial.

Approach:

• A systematic literature search was conducted in PubMed and Embase databases up to December 31, 2021.
• Eight studies encompassing 5,541 patients were included to assess GNRI's predictive value for major adverse cardiovascular and leg events (MACLEs), all-cause mortality, and amputation.

Key Points:

• Low GNRI was significantly associated with increased risks of MACLEs (RR 2.26) and all-cause mortality (RR 2.38) in PAD patients.
• A 10-unit decrease in GNRI correlated with a 36% higher risk of MACLEs and a 44% higher risk of all-cause mortality.
• GNRI did not show a significant association with amputation risk (p=0.051).

Conclusions:

• Low GNRI appears to be an independent predictor of adverse outcomes in patients with lower extremity PAD.
• Routine nutritional status screening using GNRI can provide valuable prognostic information for PAD patients.
• Further research may explore the clinical utility of GNRI in PAD management strategies.