Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

43
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
43
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

30
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
30
Vascular Spasm01:16

Vascular Spasm

1.8K
The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
1.8K
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

21
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
21
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

28
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
28
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

70
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
70

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transcatheter Mitral Edge-to-Edge Repair With Intra-Aortic Balloon Pump Support in Severe Left Ventricular Dysfunction.

JACC. Case reports·2026
Same author

Leadless pacing-induced pacemaker syndrome managed with atrial leadless pacing device.

HeartRhythm case reports·2026
Same author

Erdheim-Chester Disease: A Rare Presentation With Atrial Flutter and Severe Sinus Node Dysfunction.

JACC. Case reports·2026
Same author

Clinical Outcomes of Atrial Septal Defect and Patent Foramen Ovale After Percutaneous Closure: A 10-Year Retrospective Analysis.

Cureus·2026
Same author

Role of Transcatheter Structural Interventions in Pregnant Women.

Interventional cardiology (London, England)·2025
Same author

The Impact of LED Light Spectra on the Growth, Yield, Physiology, and Sweetness Compound of <i>Stevia rebaudiana</i>.

Biology·2025
Same journal

Immunohistochemistry (IHC) Versus Genomic Profiling in Cancer: Roles in Precision Medicine.

Cureus·2026
Same journal

Pediatric Nasal Tip Reconstruction After a Donkey Bite Using an Expanded Paramedian Forehead Flap With Conchal Cartilage Grafts: A Case Report.

Cureus·2026
Same journal

Splenic Rupture: A Delayed and Rare Complication of Colonoscopy.

Cureus·2026
Same journal

Super-refractory Status Epilepticus in Febrile Infection-Related Epilepsy Syndrome Triggered by Influenza A: A Pediatric Case Report.

Cureus·2026
Same journal

Comparative Evaluation of Serum Peroxiredoxin 2 (PRDX2), Serum Peroxiredoxin 4 (PRDX4), and Plasma Methylated Septin 9 (mSEPT9) Levels Against Conventional Biomarkers for Early Detection of Colorectal Cancer: A Study Protocol.

Cureus·2026
Same journal

Inspiratory Muscle Training for Patients With Chronic Obstructive Pulmonary Disease: A Narrative Review.

Cureus·2026
See all related articles

Related Experiment Video

Updated: Sep 5, 2025

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
08:38

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Published on: November 8, 2015

17.0K

Tacrolimus-Induced Diffuse Coronary Artery Spasm.

Abadil Samer1, Fahad Almehmadi1, Ahmed Krimly2

  • 1Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU.

Cureus
|July 11, 2022
PubMed
Summary
This summary is machine-generated.

Prinzmetal angina, or vasospastic angina, involves temporary coronary artery narrowing often causing ST-segment elevation. Diagnosis requires electrocardiogram, echocardiogram, and coronary angiography to rule out other heart conditions.

Keywords:
coronary artery spasmimmunosuppressantrenal failuresolid organ transplanttacrolimus

More Related Videos

Intracoronary Acetylcholine Provocation Testing for Assessment of Coronary Vasomotor Disorders
06:39

Intracoronary Acetylcholine Provocation Testing for Assessment of Coronary Vasomotor Disorders

Published on: August 18, 2016

15.9K
Testing Acetylcholine Followed by Adenosine for Invasive Diagnosis of Coronary Vasomotor Disorders
05:58

Testing Acetylcholine Followed by Adenosine for Invasive Diagnosis of Coronary Vasomotor Disorders

Published on: February 3, 2021

3.7K

Related Experiment Videos

Last Updated: Sep 5, 2025

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
08:38

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Published on: November 8, 2015

17.0K
Intracoronary Acetylcholine Provocation Testing for Assessment of Coronary Vasomotor Disorders
06:39

Intracoronary Acetylcholine Provocation Testing for Assessment of Coronary Vasomotor Disorders

Published on: August 18, 2016

15.9K
Testing Acetylcholine Followed by Adenosine for Invasive Diagnosis of Coronary Vasomotor Disorders
05:58

Testing Acetylcholine Followed by Adenosine for Invasive Diagnosis of Coronary Vasomotor Disorders

Published on: February 3, 2021

3.7K

Area of Science:

  • Cardiology
  • Vascular Medicine

Background:

  • Prinzmetal angina, also termed vasospastic angina, is characterized by intermittent coronary artery narrowing.
  • This condition can be focal or diffuse and may present with transient ST-segment elevation on an electrocardiogram.
  • Atherosclerotic lesions may coexist at the site of coronary artery spasm.

Observation:

  • Vasospastic angina can be triggered by various medications, including illicit drugs like cocaine.
  • Other common triggers include catecholamines (epinephrine, norepinephrine, dopamine) and parasympathomimetic agents (acetylcholine, methacholine).
  • Tacrolimus is a rare cause of drug-induced vasospastic angina.

Findings:

  • Clinical evaluation typically involves an electrocardiogram and echocardiogram.
  • Coronary angiography is the gold standard for confirming the diagnosis of vasospastic angina.
  • Cardiac catheterization is essential to exclude underlying coronary artery disease.

Implications:

  • Accurate diagnosis of vasospastic angina is crucial for appropriate management.
  • Identifying and avoiding trigger medications is a key aspect of treatment.
  • Distinguishing vasospastic angina from atherosclerotic coronary artery disease is vital for patient outcomes.