Related Experiment Video
Updated: Sep 5, 2025
05:45
Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
Published on: July 31, 2017
9.7K
Glomangiomatosis - immunohistochemical study: A case report.
Ruo-Chen Wu1, Ying-Hua Gao1, Wen-Wen Sun1
1Department of Pathology, The Second Affiliated Hospital of Shandong First Medical University, Taian 271000, Shandong Province, China.
World Journal of Clinical Cases
|July 11, 2022
Summary
Glomangiomatosis, a rare diffuse glomus tumor, presented as multiple nodules in a 55-year-old woman. This case highlights the rarity of multiple nodules and successful resection without recurrence.
Area of Science:
- Vascular Tumors
- Soft Tissue Pathology
- Dermatopathology
Background:
- Glomangiomatosis, a rare variant of glomus tumors (5% of glomus tumors), is exceptionally uncommon.
- Glomus tumors represent only 2% of all soft tissue tumors, with glomangiomatosis being even rarer.
- Malignant glomus tumor identification criteria remain undefined, despite potential for invasive growth.
Observation:
- A 55-year-old Chinese woman presented with multiple soft tissue nodular masses on her right foot and calf.
- Histopathological examination and immunohistochemical analysis were performed on the resected tumor.
- The case involved diffuse glomangiomatosis with multiple distinct nodular masses.
Findings:
- Microscopic analysis revealed nested vascular globular cells adjacent to blood vessel walls.
- Immunohistochemistry showed strong positivity for smooth muscle actin, vimentin, type IV collagen, and Bcl-2.
- Weak positivity for caldesmon, partial for CD34, and slight for calponin were noted.
Implications:
- This case contributes to the limited literature (15 reported clinicopathological analyses) on glomangiomatosis.
- Successful surgical resection of glomangiomatosis with no recurrence at one year post-operation.
- Further research is needed to establish definitive diagnostic criteria for malignant glomus tumors.
