Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Cochlea01:13

The Cochlea

45.8K
The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
45.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single-Cell Profiling of the Developing Organ of Corti Identifies Etv4/5/1 as Key Regulators of Pillar Cell Identity.

bioRxiv : the preprint server for biology·2026
Same author

Single cell analysis of developing Merkel cells reveals the emergence of non-coding RNA biotypes as a hallmark of terminal differentiation.

Cell death and differentiation·2026
Same author

CASZ1 regulates the rate at which outer hair cells mature and is required for hearing.

bioRxiv : the preprint server for biology·2025
Same author

Wnt/PKC Signaling Inhibits Sensory Hair Cell Formation in the Developing Mammalian Cochlea.

Cells·2025
Same author

Ectoderm barcoding reveals neural and cochlear compartmentalization.

Science (New York, N.Y.)·2025
Same author

Jag1 represses Notch activation in lateral supporting cells and inhibits an outer hair cell fate in the medial cochlea.

Development (Cambridge, England)·2024

Related Experiment Video

Updated: Sep 5, 2025

Neonatal Murine Cochlear Explant Technique as an In Vitro Screening Tool in Hearing Research
08:30

Neonatal Murine Cochlear Explant Technique as an In Vitro Screening Tool in Hearing Research

Published on: June 8, 2017

17.9K

Cochlear Development; New Tools and Approaches.

Matthew W Kelley1

  • 1Laboratory of Cochlear Development, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, United States.

Frontiers in Cell and Developmental Biology
|July 11, 2022
PubMed
Summary
This summary is machine-generated.

This review explores cellular specification in the mammalian cochlea, focusing on the organ of Corti. Single-cell RNA sequencing reveals new insights into the development of sensory hair cells and other cell types from prosensory cells.

Keywords:
cell fatehair cellhearingorgan of corti (OC)single cell RNA sequencing

More Related Videos

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration
12:21

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration

Published on: November 26, 2015

17.6K
Culture of Embryonic Mouse Cochlear Explants and Gene Transfer by Electroporation
09:03

Culture of Embryonic Mouse Cochlear Explants and Gene Transfer by Electroporation

Published on: January 12, 2015

13.0K

Related Experiment Videos

Last Updated: Sep 5, 2025

Neonatal Murine Cochlear Explant Technique as an In Vitro Screening Tool in Hearing Research
08:30

Neonatal Murine Cochlear Explant Technique as an In Vitro Screening Tool in Hearing Research

Published on: June 8, 2017

17.9K
The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration
12:21

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration

Published on: November 26, 2015

17.6K
Culture of Embryonic Mouse Cochlear Explants and Gene Transfer by Electroporation
09:03

Culture of Embryonic Mouse Cochlear Explants and Gene Transfer by Electroporation

Published on: January 12, 2015

13.0K

Area of Science:

  • Developmental Biology
  • Auditory Neuroscience
  • Genomics

Background:

  • The mammalian cochlea's organ of Corti contains diverse cell types, including mechanosensory hair cells, all originating from prosensory precursor cells.
  • Understanding the precise developmental pathways and signaling networks governing cell specification in the organ of Corti has been challenging due to its small size and limited cell numbers.

Purpose of the Study:

  • To review current knowledge on cellular specification within the cochlea.
  • To discuss methodologies for single-cell RNA sequencing (scRNA-seq) applicable to cochlear development.
  • To highlight novel findings from a recent scRNA-seq study on cochlear cell specification.

Main Methods:

  • Review of existing literature on cochlear development and cell specification.
  • Discussion of single-cell RNA sequencing techniques and their application.
  • Analysis of a specific study utilizing scRNA-seq for cochlear cell specification.

Main Results:

  • Single-cell RNA sequencing offers advanced capabilities for dissecting cellular heterogeneity and developmental trajectories.
  • Recent scRNA-seq data has provided unprecedented resolution into the specification of various cell types within the organ of Corti.
  • These findings enhance our understanding of the molecular mechanisms driving cell fate decisions during cochlear development.

Conclusions:

  • scRNA-seq is a powerful tool for advancing our understanding of complex developmental processes in the cochlea.
  • New insights from scRNA-seq studies are crucial for unraveling the intricate mechanisms of sensory cell development.
  • Continued application of these techniques promises further discoveries in auditory development and regeneration.