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Related Concept Videos

Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

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A Protocol to Evaluate and Quantify Retinal Pigmented Epithelium Pathologies in Mouse Models of Age-Related Macular Degeneration
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Subretinal drusenoid deposits: An update.

Manuel Monge1, Adriana Araya2, Lihteh Wu2,3

  • 1Department of Ophthalmology, Hospital México, San José, Costa Rica.

Taiwan Journal of Ophthalmology
|July 11, 2022
PubMed
Summary
This summary is machine-generated.

Subretinal drusenoid deposits (SDDs), distinct from drusen, are key indicators of advanced age-related macular degeneration (AMD). Early detection via multimodal imaging is crucial as SDDs significantly increase the risk of vision-threatening complications.

Keywords:
Age-related macular degenerationouter retinal atrophypseudodrusenreticular drusenreticular macular diseasereticular pseudodrusenretinal angiomatous proliferationsubretinal drusenoid deposittype 3 macular neovascularization

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Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Macular Degeneration

Background:

  • Age-related macular degeneration (AMD) presents diverse phenotypes.
  • Drusen, beneath the retinal pigment epithelium (RPE), are a hallmark of AMD.
  • Subretinal drusenoid deposits (SDDs), or reticular pseudodrusens, are located atop the RPE.

Purpose of the Study:

  • To highlight the diagnostic challenges and clinical significance of SDDs in AMD.
  • To emphasize the association of SDDs with rod function and retinal sensitivity.
  • To underscore the predictive value of SDDs for late AMD development.

Main Methods:

  • Review of clinical examinations and multimodal imaging techniques for SDD detection.
  • Analysis of the topographical and functional relationship between SDDs and retinal rods.
  • Longitudinal observation of SDD dynamics and progression to late AMD stages.

Main Results:

  • SDDs are difficult to detect with standard clinical examination and fundus photography, necessitating multimodal imaging.
  • SDDs are topographically and functionally linked to retinal rods, causing significant impairment in retinal sensitivity and dark adaptation.
  • SDDs are dynamic, potentially growing, fusing, or regressing, and can precede acquired vitelliform lesions.
  • The presence of SDDs is a strong predictor of progression to late AMD, including macular neovascularization, geographic atrophy, and outer retinal atrophy.

Conclusions:

  • SDDs represent a distinct entity from drusen with significant implications for AMD progression.
  • Multimodal imaging is essential for accurate diagnosis and risk assessment in patients with SDDs.
  • SDDs are critical indicators of high risk for developing vision-threatening complications of late AMD.