2D layered nanomaterials for therapeutics delivery

Area of Science:

• Biomedical Engineering
• Materials Science
• Nanotechnology

Background:

• Two-dimensional (2D) nanomaterials are ultrathin, layered materials with high surface-to-volume ratios.
• They are capable of delivering various therapeutics, including small molecules, peptides, and proteins.
• Their properties allow for high drug loading and sustained or triggered release.

Purpose of the Study:

• To evaluate 2D nanomaterials for therapeutic delivery applications.
• To highlight their unique physical and chemical characteristics relevant to drug delivery.
• To discuss their biological stability and therapeutic delivery capabilities.

Main Methods:

• Review of literature on 2D nanomaterials for biomedical applications.
• Analysis of physical and chemical properties influencing drug delivery.
• Assessment of biological stability and degradation profiles.

Main Results:

• A wide range of 2D nanomaterials (e.g., graphene, TMDs, MOFs) show potential for drug delivery.
• High surface area enables efficient therapeutic loading and controlled release kinetics.
• Many 2D nanomaterials exhibit biocompatibility and degrade into non-toxic byproducts.

Conclusions:

• 2D nanomaterials are versatile platforms for advanced therapeutic delivery systems.
• Their tunable properties and biocompatibility make them suitable for various biomedical applications.
• Ongoing research focuses on optimizing 2D nanomaterials for enhanced drug delivery efficacy and safety.