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Platanosides, a Potential Botanical Drug Combination, Decrease Liver Injury Caused by Acetaminophen Overdose in Mice.

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Platanosides (PTSs) from American sycamore protect against acetaminophen-induced liver damage by reducing oxidative stress and inflammation. These botanical compounds also show promise for treating drug-resistant infections.

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Area of Science:

  • Pharmacology
  • Toxicology
  • Natural Products Chemistry

Background:

  • Acetaminophen (APAP) overdose causes significant hepatotoxicity, often linked to oxidative stress.
  • Platanosides (PTSs), a novel botanical compound class from *Platanus occidentalis*, exhibit antioxidant properties and potential as antibiotics.

Purpose of the Study:

  • To investigate the hepatoprotective effects of PTSs against APAP-induced liver injury.
  • To assess the combined potential of PTSs and APAP for managing infectious diseases and associated symptoms.

Main Methods:

  • Administered PTSs to mice with APAP-induced hepatotoxicity.
  • Measured serum alanine aminotransferase (ALT) levels and hepatic necrosis.
  • Assessed oxidative stress markers (4-hydroxynonenal) and inflammatory pathways (iNOS, JNK activation).
  • Utilized computational studies to predict PTSs' molecular targets (JNK-1/2, Keap1-Nrf2).

Main Results:

  • PTS treatment significantly reduced ALT release, hepatic necrosis, and 4-hydroxynonenal levels.
  • PTSs decreased inducible nitric oxide synthase (iNOS) expression and c-Jun N-terminal kinase (JNK) activation.
  • Computational analysis suggested PTSs inhibit JNK-1/2 and Keap1-Nrf2, with potential for enhanced efficacy from isomeric mixtures.

Conclusions:

  • Platanosides (PTSs) demonstrate significant hepatoprotective effects against APAP-induced toxicity by mitigating oxidative stress and inflammation.
  • PTSs show promise as botanical drugs for both liver protection and combating drug-resistant bacterial infections.