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Updated: Sep 5, 2025

Tuning Degradation to Achieve Specific and Efficient Protein Depletion
Published on: July 20, 2019
Intrinsic and extrinsic regulators of Aux/IAA protein degradation dynamics
Marcelo Rodrigues Alves de Figueiredo1, Lucia C Strader1
1Department of Biology, Duke University, Durham, NC, USA.
Abstract:
The plant hormone auxin acts through regulated degradation of Auxin/INDOLE-3-ACETIC ACID (Aux/IAA) proteins to regulate transcriptional events. In this review, we examine the composition and function of each Aux/IAA structural motif. We then focus on recent characterization of Aux/IAA N-terminal disordered regions, formation of secondary structure within these disordered regions, and post-translational modifications (PTMs) that affect Aux/IAA function and stability. We propose how structural variations between Aux/IAA family members may be tuned for differential transcriptional repression and degradation dynamics.
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