Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

548
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
548
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents01:18

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

199
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
199
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

138
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
138
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

200
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
200
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

427
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
427
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

534
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
534

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Montgomery Tubercles in the Male Areola: Histological Observations and a Brief About Past Investigators.

The American Journal of dermatopathology·2026
Same author

Pioneering medical journals of Japan.

The National medical journal of India·2026
Same author

Vascular involvement in endometriosis and adenomyosis.

American journal of obstetrics and gynecology·2025
Same author

Rahel Zipkin, Sophia Getzowa, Elisabeth Sanderson-Damberg: Three Women From Early-20th-Century Bern, Switzerland-Their Lives, Research, and Impact on Pathology of the Thyroid.

Archives of pathology & laboratory medicine·2025
Same author

A Systematic Approach to the Histologic Evaluation of Terminal Ileal Biopsies.

International journal of surgical pathology·2025
Same author

Medical education in India: Disturbing trends.

Indian journal of medical ethics·2025

Related Experiment Video

Updated: Sep 5, 2025

Ileectomy-induced Bile Overaccumulation in Mouse Intestine
06:55

Ileectomy-induced Bile Overaccumulation in Mouse Intestine

Published on: August 21, 2017

9.6K

Typhoid appendicitis and 'the man from Istanbul'.

Angelina Mendos1, Sanjay A Pai1

  • 1Department of Pathology and Laboratory Medicine, Manipal Hospital Yeshwanthpur, Malleswaram, Bengaluru 560055, Karnataka, India.

The National Medical Journal of India
|July 11, 2022
PubMed
Summary

Typhoid appendicitis, a rare condition, was identified in a young female patient. Macrophage aggregates in the appendix suggest Salmonella Typhi infection, aiding diagnosis even without positive blood cultures.

Area of Science:

  • Pathology
  • Infectious Diseases
  • Microbiology

Background:

  • Typhoid fever is a systemic infection caused by Salmonella enterica serovar Typhi.
  • Appendicitis is a common surgical emergency, but typhoid appendicitis is rare.
  • Histopathological examination of appendectomy specimens is crucial for diagnosing abdominal pathologies.

Observation:

  • A 19-year-old female presented with symptoms suggestive of appendicitis.
  • Histopathological analysis of the surgically removed appendix revealed significant aggregates of macrophages within the mucosal and wall layers.
  • Blood cultures confirmed the presence of Salmonella enterica serovar Typhi.

Findings:

  • The appendix exhibited characteristic histopathological changes indicative of typhoid infection.

More Related Videos

Handheld Metal Detector Screening for Metallic Foreign Body Ingestion in Children
04:55

Handheld Metal Detector Screening for Metallic Foreign Body Ingestion in Children

Published on: September 11, 2018

10.9K
An Allelotyping PCR for Identifying Salmonella enterica serovars Enteritidis, Hadar, Heidelberg, and Typhimurium
12:18

An Allelotyping PCR for Identifying Salmonella enterica serovars Enteritidis, Hadar, Heidelberg, and Typhimurium

Published on: July 22, 2011

21.9K

Related Experiment Videos

Last Updated: Sep 5, 2025

Ileectomy-induced Bile Overaccumulation in Mouse Intestine
06:55

Ileectomy-induced Bile Overaccumulation in Mouse Intestine

Published on: August 21, 2017

9.6K
Handheld Metal Detector Screening for Metallic Foreign Body Ingestion in Children
04:55

Handheld Metal Detector Screening for Metallic Foreign Body Ingestion in Children

Published on: September 11, 2018

10.9K
An Allelotyping PCR for Identifying Salmonella enterica serovars Enteritidis, Hadar, Heidelberg, and Typhimurium
12:18

An Allelotyping PCR for Identifying Salmonella enterica serovars Enteritidis, Hadar, Heidelberg, and Typhimurium

Published on: July 22, 2011

21.9K
  • The presence of macrophages in the appendix is a key diagnostic indicator for typhoid fever.
  • Microbiological confirmation of Salmonella Typhi was obtained from blood cultures.

    • Implications:

    • Pathologists should consider typhoid fever in the differential diagnosis of appendicitis, especially when observing macrophage aggregates.
    • This case highlights the importance of integrating histopathology with clinical and microbiological data for accurate diagnosis.
    • Early and accurate diagnosis of typhoid appendicitis can prevent complications and guide appropriate treatment.