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Multifocal motor neuropathy after SARS-CoV-2 vaccination: a causal or coincidental association?

Fettah Eren1, Recep Aygul1, Sevde Tenekeci1

  • 1Selcuk University, School of Medicine, Department of Neurology, Konya, Turkey.

The Journal of International Medical Research
|July 12, 2022
PubMed

Insights

Multifocal motor neuropathy (MMN) is a rare condition. This study reports the first case of MMN developing after the Pfizer-BioNTech COVID-19 vaccine, highlighting a potential neurological complication.

Area of Science:

  • Neurology
  • Immunology
  • Vaccinology

Background:

  • Multifocal motor neuropathy (MMN) is an immune-mediated demyelinating polyneuropathy affecting motor nerves.
  • While various neuropathies have been reported post-SARS-CoV-2 vaccination, MMN has not been previously documented.

Observation:

  • A case of MMN is presented in a patient who developed progressive muscle weakness after the second dose of the Pfizer-BioNTech mRNA vaccine.
  • Diagnosis was confirmed through clinical assessment and electroneuromyography.

Findings:

  • This is the first reported instance of MMN occurring subsequent to SARS-CoV-2 vaccination.
  • The temporal association suggests a potential link between the vaccine and MMN development.

Implications:

  • This case expands the spectrum of potential neurological adverse events associated with SARS-CoV-2 vaccines.
  • Further investigation is warranted to understand the immunopathological mechanisms and incidence of MMN post-vaccination.
Keywords:
Motor neuropathySARS-CoV-2coronavirus disease 2019muscle weaknesspolyneuropathyvaccination

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