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Progress of Polysaccharide-Contained Polyurethanes for Biomedical Applications.

Do-Bin Ju1, Jeong-Cheol Lee1, Soo-Kyung Hwang2,3

  • 1Department of Agricultural Biotechnology, Seoul National University, Seoul, 08824, Korea.

Tissue Engineering and Regenerative Medicine
|July 12, 2022
PubMed
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This study explores bio-based polyurethane (PU) materials containing polysaccharides (PS). These novel PU-PS composites offer enhanced biocompatibility and degradability for biomedical applications like wound dressings and bone tissue engineering.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Polyurethane (PU) is widely used in biomedical applications due to its favorable mechanical properties and tailorable foam structures.
  • Concerns regarding plastic waste have driven the development of bio-based alternatives, particularly in the last decade.
  • Traditional PUs face limitations in bio-acceptability, biodegradability, and controlled drug delivery.

Purpose of the Study:

  • To discuss the potential of polysaccharide (PS)-contained polyurethane (PU) as a bio-based material.
  • To highlight the advantages of incorporating polysaccharides into PU for biomedical applications.
  • To address the limitations of conventional PUs by integrating PS components.

Main Methods:

  • Literature review and discussion on the properties of polysaccharide-contained polyurethanes.
Keywords:
Bone tissue engineeringPolysaccharidePolyurethaneWound dressing

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  • Analysis of the benefits of polysaccharides, including biocompatibility, degradability, and cost-effectiveness.
  • Exploration of the structural features enabling chemical modification for tailored applications.

    • Main Results:

    • Polysaccharide-contained PUs demonstrate improved biocompatibility and biodegradability compared to traditional PUs.
    • The incorporation of PS facilitates the integration of bioactive agents and offers cost-effectiveness.
    • These composite materials show promise for wound dressing and bone tissue engineering applications.

    Conclusions:

    • Bio-based polyurethanes incorporating polysaccharides present a sustainable and advantageous alternative for biomedical uses.
    • The synergistic properties of PU and PS can overcome the limitations of standalone PU materials.
    • Further research into PU-PS composites is warranted for advanced wound healing and regenerative medicine.