A general approach to S-rhodamines from diaryl thioethers and their application in constructing pH probes
Dongsheng Sun1, Shixu Yang2, Junxia Ma3
1Department of Basic Medicine, Medical College, Taizhou University, Taizhou, Zhejiang 318000, China.
Abstract:
A general strategy for the efficient preparation of S-rhodamines from the condensation of diaryl thioether and 2-carboxybenzaldehydes was reported. We further took a morpholine containing spirolactam structure as an example to illustrate that these S-rhodamine dyes could be utilized to construct fluorescent probes based on the ring-opening process. This work provided a general approach for the synthesis of novel S-rhodamine dyes, thus possibly facilitating the development of fluorescence imaging.
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