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Updated: Sep 5, 2025

The Measurement and Treatment of Suppression in Amblyopia

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Published on: December 14, 2012

Suppression without inhibition: how retinal computation contributes to saccadic suppression.

Saad Idrees^1,2,3, Matthias-Philipp Baumann^1,4, Maria M Korympidou^1,2,5

¹Werner Reichardt Centre for Integrative Neuroscience, University of Tübingen, 72076, Tübingen, Germany.

Communications Biology

|July 13, 2022

Summary

Researchers uncovered three retinal mechanisms that reduce visual sensitivity during saccadic eye movements. These findings explain how vision remains stable despite rapid eye motion, revealing key aspects of visual processing.

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Last Updated: Sep 5, 2025

The Measurement and Treatment of Suppression in Amblyopia

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Published on: December 14, 2012

How to Create and Use Binocular Rivalry

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Published on: November 10, 2010

Investigating the Deployment of Visual Attention Before Accurate and Averaging Saccades via Eye Tracking and Assessment of Visual Sensitivity

Investigating the Deployment of Visual Attention Before Accurate and Averaging Saccades via Eye Tracking and Assessment of Visual Sensitivity

Published on: March 18, 2019

Area of Science:

Neuroscience
Vision Science
Retinal Physiology

Background:

Visual perception is remarkably stable during saccadic eye movements, despite significant visual disruption.
Saccadic suppression, a reduction in visual sensitivity originating in the retina, contributes to this stability.
The precise retinal circuit mechanisms underlying saccadic suppression remain largely unknown.

Purpose of the Study:

To elucidate the retinal circuit mechanisms responsible for saccadic suppression.
To investigate how the retina processes sequential visual stimuli during eye movements.

Main Methods:

Electrophysiology in mouse, pig, and macaque retinas.
Two-photon calcium imaging.
Computational modeling and human psychophysics.

Main Results:

Three independent suppressive mechanisms were identified in the retina triggered by sequential stimuli.
The primary mechanism involves temporal filtering and downstream nonlinearities in cone photoreceptors, not inhibition or adaptation.
Two additional mechanisms, primarily affecting ON ganglion cells, originate in the receptive field surround.

Conclusions:

These findings reveal novel retinal circuit mechanisms contributing to saccadic suppression.
The uncovered mechanisms are crucial for maintaining visual stability during natural viewing conditions involving eye movements.
Disparities in suppression mechanisms between ON and OFF retinal ganglion cells were highlighted.