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Anthocyanins' effects on diabetes mellitus and islet transplantation

Yang Liu1, Qianwen Wang1, Kangze Wu2

  • 1The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, China.

Critical Reviews in Food Science and Nutrition
|July 13, 2022
PubMed

Insights

Anthocyanins show promise in combating diabetes mellitus and improving islet transplantation outcomes. These natural compounds may help manage blood sugar, reduce inflammation, and protect against oxidative stress, offering a potential new approach to diabetes care.

Area of Science:

  • Nutritional Science
  • Endocrinology
  • Pharmacology

Background:

  • Diabetes mellitus incidence is rising globally, posing a significant health burden.
  • Current treatments for diabetes and islet transplantation face limitations due to adverse effects and oxidative stress.
  • Novel therapeutic strategies are urgently needed to address the growing challenges of diabetes management.

Purpose of the Study:

  • To review the health effects of anthocyanins on diabetes mellitus.
  • To explore the potential benefits of anthocyanins in islet transplantation.
  • To elucidate the mechanisms underlying anthocyanin's effects on metabolic health and inflammation.

Main Methods:

  • Analysis of epidemiological studies on anthocyanin intake and diabetes risk.
  • Review of animal and clinical studies investigating anthocyanin efficacy in diabetes and complications.
  • Examination of research on anthocyanins' impact on pancreatic islet function and post-transplantation outcomes.

Main Results:

  • Moderate anthocyanin intake is associated with a reduced risk of developing diabetes mellitus.
  • Anthocyanins demonstrate positive effects in preventing and treating diabetes and its complications.
  • Mechanisms include improved glucose/lipid metabolism, insulin resistance, antioxidant, and anti-inflammatory activities.
  • Anthocyanins enhance pancreatic islet damage repair and function post-transplantation.

Conclusions:

  • Anthocyanins show potential for preventing diabetes in healthy individuals and as a supplementary treatment for diabetes mellitus.
  • Anthocyanins may improve outcomes for islet transplantation by mitigating oxidative stress.
  • Further research is required to fully understand the health benefits and therapeutic potential of anthocyanins.
Keywords:
Anthocyaninsdiabetes mellitusislet transplantationpre-diabetes

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