[Modulating effect of immunotherapy with modified tumor cells in transplantable lymphoma]

Vibrio cholerici neuraminidase was studied on CBA mice for its effect on the strain NK/Ly lymphoid cells oncogenicity in intraabdominal transplantation. The 30% decrease in transplantability of cells treated by the enzyme in the dose of 50 U/ml was established. The modulating effect of specific active immunotherapy by modified cells in lymphoma was also studied. A pronounced stimulation of immunity T-cell links and proliferation in immunocompetent organs, an increase in the number of large granular lymphocytes in blood, specific antibody formation suppression were established. The problem of neuraminidase nonspecific effect on the tumour cells is under discussion.