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Assessment of Gastric Emptying in Non-obese Diabetic Mice Using a [13C]-octanoic Acid Breath Test
Published on: March 23, 2013
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GASTROINTESTINAL MOTILITY IN ELDERLY PATIENTS WITH WELL-CONTROLLED TYPE 2 DIABETES MELLITUS
Erika M A B Sena1, Dianna V L Silva2, Madileine F Américo3
1Universidade Federal de Alagoas, Hospital Universitário Professor Alberto Antunes, Maceió, AL, Brasil.
Arquivos De Gastroenterologia
|July 13, 2022
Summary
This study found that well-controlled type 2 diabetes mellitus (T2DM) did not significantly alter gastrointestinal transit in elderly patients. However, aging itself may affect gastric electrical activity, regardless of diabetes status.
Area of Science:
- Gastroenterology
- Endocrinology
- Geriatrics
Background:
- Gastrointestinal (GI) motility disorders are prevalent in type 2 diabetes mellitus (T2DM).
- Understanding GI transit and gastric activity in elderly T2DM patients on metformin is limited.
Purpose of the Study:
- To assess GI transit and gastric myoelectric activity in elderly T2DM patients treated with metformin.
- To compare these parameters with age-matched non-diabetic controls and younger healthy individuals.
Main Methods:
- Employed non-invasive techniques: alternating current biosusceptometry and electrogastrography.
- Monitored GI transit and gastric contractility after a standardized meal using magnetic markers.
- Included three groups: young non-diabetic (n=10), elderly non-diabetic (n=10), and elderly T2DM on metformin (n=10).
Main Results:
- No significant differences in mean gastric emptying, colon arrival, or intestinal transit times were observed between the groups.
- Gastric myoelectric activity (frequency, amplitude) showed no intergroup differences.
- Both elderly diabetic and non-diabetic groups exhibited slightly higher abnormal rhythmic index and half-bandwidth compared to young adults.
Conclusions:
- Good glycemic control in T2DM patients does not appear to alter gastric emptying or intestinal transit.
- Observed changes in gastric electrical activity may be attributable to the aging process rather than T2DM itself.
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