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CaMKII binds both substrates and activators at the active site

Can Özden1, Roman Sloutsky2, Tomohiro Mitsugi3

  • 1Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA; Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA 01003, USA.

Cell Reports
|July 13, 2022
PubMed
Summary

Calcium/calmodulin-dependent protein kinase II (CaMKII) activation for long-term memory is not explained by the two-site model. High-affinity binding partners kinetically compete with autoinhibition to sustain CaMKII activity.

Keywords:
AMPA-type glutamate receptorCP: Molecular biologyCa(2+)/calmodulin dependent protein kinase IILTPNMDA-type glutamate receptorTiam1X-ray crystallography

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