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Related Experiment Video

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Intracranial Pharmacotherapy and Pain Assays in Rodents

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Targeting Affective Mood Disorders With Ketamine to Prevent Chronic Postsurgical Pain.

Dianna E Willis^1,2, Peter A Goldstein^2,3,4

¹Burke Neurological Institute, White Plains, NY, United States.

Frontiers in Pain Research (Lausanne, Switzerland)

|July 14, 2022

Summary

This summary is machine-generated.

Ketamine, an essential anesthetic and analgesic, may prevent chronic pain development. This review explores its non-NMDA receptor effects on pain and mood disorders, focusing on human trials.

Keywords:

HCN channel dissociation ketamine oceanic boundlessness out-of-body experience pain

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Area of Science:

Anesthesiology
Pain Medicine
Psychiatry

Background:

Ketamine is an essential medicine for anesthesia and acute pain relief.
Sub-anesthetic ketamine shows potential for chronic pain and treatment-resistant depression.
Postoperative pain and pre-existing mood disorders are risk factors for chronic postsurgical pain.

Purpose of the Study:

To review ketamine's effects on pain perception and mood disorders.
To focus on non-NMDA receptor-mediated mechanisms.
To emphasize findings from human clinical trials.

Main Methods:

Literature review of ketamine's effects.
Focus on biopsychological processes in pain and mood.
Emphasis on human trial data.

Main Results:

Ketamine's established efficacy in anesthesia and acute pain.
Emerging evidence for chronic pain and depression treatment.
Understanding of non-NMDA receptor roles in pain and mood.

Conclusions:

Ketamine's potential to prevent chronic postsurgical pain warrants further investigation.
Non-NMDA receptor pathways are crucial for ketamine's therapeutic effects.
Human trials are key to validating ketamine's broader applications.