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Updated: Sep 4, 2025

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
Synthetic Approaches to the New Drugs Approved During 2020
Andrew C Flick1, Carolyn A Leverett2, Hong X Ding3
1Takeda Pharmaceuticals, 9625 Towne Centre Drive, San Diego, California 92121, United States.
Abstract:
New drugs introduced to the market are privileged structures that have affinities for biological targets implicated in human diseases and conditions. These new chemical entities (NCEs), particularly small molecules and antibody-drug conjugates (ADCs), provide insight into molecular recognition and simultaneously function as leads for the design of future medicines. This Review is part of a continuing series presenting the most likely process-scale synthetic approaches to 44 new chemical entities approved for the first time anywhere in the world during 2020.
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