Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Survival Analysis01:21

Cancer Survival Analysis

442
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
442
Radiation: Applications01:17

Radiation: Applications

1.2K
The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...
1.2K
Mismatch Repair01:20

Mismatch Repair

5.2K
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
5.2K
Isotopes and Radioisotopes01:28

Isotopes and Radioisotopes

9.6K
In the early 1900s, English chemist Frederick Soddy realized that an element could have atoms with different masses that were chemically indistinguishable. These different types are called isotopes — atoms of the same element that differ in mass. Isotopes differ in mass because they have different numbers of neutrons but are chemically identical because they have the same number of protons. Soddy was awarded the Nobel Prize in Chemistry in 1921 for this discovery.
An isotope containing...
9.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Royal College of Radiologists Guidance Statements on the Use of Auto-contouring in Radiotherapy.

Clinical oncology (Royal College of Radiologists (Great Britain))·2026
Same author

III-Nitride MEMS drum resonators on flexible metal substrates.

Microsystems & nanoengineering·2025
Same author

Disease and treatment awareness, prescription patterns, and self-medication practices in patients of functional bowel disorders: A cross-sectional survey.

Journal of postgraduate medicine·2025
Same author

The Use of Radiotherapy in the Cure of Different Cancers - Further Results From the FORTY (Favourable Outcomes From RadioTherapY) Project.

Clinical oncology (Royal College of Radiologists (Great Britain))·2025
Same author

Natural occurrence of episomal banana streak GF virus species infecting the GI-tagged banana cv. Virupakshi in India.

Physiology and molecular biology of plants : an international journal of functional plant biology·2025
Same author

Patient Experiences of Using Wearable Health Monitors During Cancer Treatment: A Qualitative Study.

Clinical oncology (Royal College of Radiologists (Great Britain))·2024
Same journal

Research Trends in Physical Activity and Breast Cancer: A 25-Year Bibliometric Analysis (2000-2025).

Clinical oncology (Royal College of Radiologists (Great Britain))·2026
Same journal

Concordance Between Planned and Delivered treatment for Head and Neck Cancer Patients Treated With Curative Intent: A Real-World Comparison of Under 70-year-olds With 70-year-olds and Over.

Clinical oncology (Royal College of Radiologists (Great Britain))·2026
Same journal

A Novel Technique for Pain Management to Deliver a Course of Palliative Radiotherapy.

Clinical oncology (Royal College of Radiologists (Great Britain))·2026
Same journal

Broad-Spectrum Antibiotics are Associated with worse Survival After Radical Treatment for Glioblastoma Multiforme: A Multicentre Study.

Clinical oncology (Royal College of Radiologists (Great Britain))·2026
Same journal

Exploring the Need for Plan Adaptation in Robustly Optimised Head and Neck Intensity Modulated Proton Therapy: A Dosimetric Perspective From Initial Institutional Experience.

Clinical oncology (Royal College of Radiologists (Great Britain))·2026
Same journal

Lifting the Lid on Best Practice in a Case of Oligometastatic Breast Cancer.

Clinical oncology (Royal College of Radiologists (Great Britain))·2026
See all related articles

Related Experiment Video

Updated: Sep 4, 2025

Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant
05:18

Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant

Published on: October 6, 2023

1.5K

An Update to the Malthus Model for Radiotherapy Utilisation in England.

S Heritage1, S Sundaram1, N F Kirkby2

  • 1School of Clinical Medicine, University of Cambridge, Cambridge, UK.

Clinical Oncology (Royal College of Radiologists (Great Britain))
|July 14, 2022
PubMed
Summary
This summary is machine-generated.

The Malthus Programme

Keywords:
Breast cancerhead and neck cancerhealth service needs and demandslung cancerprostate cancerradiotherapy

More Related Videos

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System
08:25

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Published on: April 11, 2018

15.4K
Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

7.3K

Related Experiment Videos

Last Updated: Sep 4, 2025

Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant
05:18

Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant

Published on: October 6, 2023

1.5K
Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System
08:25

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Published on: April 11, 2018

15.4K
Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

7.3K

Area of Science:

  • Oncology
  • Radiotherapy
  • Health Services Research

Background:

  • The Malthus Programme models radiotherapy demand using cancer incidence and treatment decision trees.
  • Recent advancements include increased hypofractionation and evolving indications for radiotherapy, especially for oligometastatic disease.
  • The previous model update was in 2017.

Purpose of the Study:

  • To update the Malthus Programme model for 2021, incorporating recent data and changes in radiotherapy practice.
  • To estimate the current radiotherapy fraction demand for breast, prostate, lung, and head and neck cancers in England.

Main Methods:

  • Updated decision trees for four major cancer sites based on practice-changing trials, guidelines, audit data, and expert opinion.
  • Incorporated site- and stage-specific cancer incidence data from the National Disease Registration Service.
  • Estimated the appropriate rate of radiotherapy and fraction demand per million population at national and local levels.

Main Results:

  • The updated model predicts an 11.4% decrease in total radiotherapy fraction demand across the four cancer sites compared to the 2017 model.
  • This reduction is primarily attributed to increased use of hypofractionated treatments, including stereotactic ablative radiotherapy, and earlier cancer stage presentation.
  • An absolute decrease of 3% in the appropriate rate of radiotherapy was observed for lung cancer.

Conclusions:

  • The 2021 Malthus Programme model indicates a reduction in radiotherapy fraction demand in England.
  • Hypofractionation of radiotherapy regimens is the principal driver of this decrease.
  • Increasing treatment complexity and local service factors must be considered when assessing radiotherapy service capacity and throughput.