Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disruption of the brain-spleen axis impairs monocyte-microglia communication and accelerates disease progression in a mouse model of amyloidosis.

Nature communications·2026
Same author

The functional impact of LGI1 autoantibodies on human CA3 pyramidal neurons.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

IgLON5 autoimmune antibodies activate Tau via neuronal hyperactivity.

Science advances·2026
Same author

PinkyCaMP: an mScarlet-based calcium sensor with enhanced brightness, photostability and multiplexing capabilities.

Nature methods·2026
Same author

Multicolor photoreactions of the red light-activated channelrhodopsin Chrimson.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Optogenetic silencing by combining a rhodopsin cyclase with an engineered cGMP-gated potassium channel.

Science advances·2025
Same journal

Neural timescales from a computational perspective.

Nature neuroscience·2026
Same journal

Author Correction: Spinal cord Tau pathology induces tactile deficits and cognitive impairment in Alzheimer's disease via dysregulation of CCK neurons.

Nature neuroscience·2026
Same journal

Hippocampal theta sweeps indicate goal direction during navigation.

Nature neuroscience·2026
Same journal

Just how goal-directed are hippocampal theta sweeps, anyway?

Nature neuroscience·2026
Same journal

Goal-directed hippocampal theta sweeps during memory-guided navigation.

Nature neuroscience·2026
Same journal

Connectomic evidence that ordered activity drives neuromuscular network formation.

Nature neuroscience·2026
See all related articles

Related Experiment Video

Updated: Sep 4, 2025

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex
11:31

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex

Published on: February 25, 2022

2.4K

Optogenetics at the presynapse.

Benjamin R Rost1,2, Jonas Wietek3,4, Ofer Yizhar5,6

  • 1German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany. benjamin.rost@dzne.de.

Nature Neuroscience
|July 14, 2022
PubMed
Summary
This summary is machine-generated.

Optogenetic tools are expanding beyond neuron cell bodies to control presynaptic functions, enabling precise manipulation of neurotransmitter release and synaptic plasticity at axonal terminals.

More Related Videos

Combining Optogenetics with Artificial microRNAs to Characterize the Effects of Gene Knockdown on Presynaptic Function within Intact Neuronal Circuits
09:17

Combining Optogenetics with Artificial microRNAs to Characterize the Effects of Gene Knockdown on Presynaptic Function within Intact Neuronal Circuits

Published on: March 14, 2018

10.3K
Two Different Real-Time Place Preference Paradigms Using Optogenetics within the Ventral Tegmental Area of the Mouse
05:50

Two Different Real-Time Place Preference Paradigms Using Optogenetics within the Ventral Tegmental Area of the Mouse

Published on: February 12, 2020

13.7K

Related Experiment Videos

Last Updated: Sep 4, 2025

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex
11:31

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex

Published on: February 25, 2022

2.4K
Combining Optogenetics with Artificial microRNAs to Characterize the Effects of Gene Knockdown on Presynaptic Function within Intact Neuronal Circuits
09:17

Combining Optogenetics with Artificial microRNAs to Characterize the Effects of Gene Knockdown on Presynaptic Function within Intact Neuronal Circuits

Published on: March 14, 2018

10.3K
Two Different Real-Time Place Preference Paradigms Using Optogenetics within the Ventral Tegmental Area of the Mouse
05:50

Two Different Real-Time Place Preference Paradigms Using Optogenetics within the Ventral Tegmental Area of the Mouse

Published on: February 12, 2020

13.7K

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Optogenetics

Background:

  • Optogenetics offers precise spatiotemporal control over biological processes.
  • Traditional neuroscience applications focus on somatodendritic control of neuronal activity.
  • Emerging research explores optogenetic control of presynaptic functions.

Purpose of the Study:

  • To review the presynaptic applications of optogenetic tools.
  • To discuss the unique cell biology of axonal terminals in optogenetic manipulation.
  • To outline future directions for presynaptic optogenetics.

Main Methods:

  • Utilizing presynaptically localized opsins.
  • Employing light stimulation at axonal terminals.
  • Investigating control of neurotransmitter release and synaptic plasticity.

Main Results:

  • Optogenetic tools can mediate neurotransmitter release from presynaptic terminals.
  • Presynaptic inhibition and synaptic plasticity can be induced using optogenetics.
  • Specific components of the presynaptic machinery can be manipulated.

Conclusions:

  • Optogenetics provides powerful methods for investigating presynaptic mechanisms.
  • The application of optogenetics to axonal terminals is a rapidly advancing field.
  • Further development holds promise for understanding neural circuits and disease.