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Published on: July 19, 2016
Non-monotonous dose response function of the termination of spiral wave chaos
Thomas Lilienkamp1,2, Ulrich Parlitz3,4,5, Stefan Luther6,7,8,9
1Max Planck Institute for Dynamics and Self-Organization, Göttingen, 37077, Germany. thomas.lilienkamp@ds.mpg.de.
Abstract:
The conventional termination technique of life threatening cardiac arrhythmia like ventricular fibrillation is the application of a high-energy electrical defibrillation shock, coming along with severe side-effects. In order to improve the current treatment reducing these side-effects, the application of pulse sequences of lower energy instead of a single high-energy pulse are promising candidates. In this study, we show that in numerical simulations the dose-response function of pulse sequences applied to two-dimensional spiral wave chaos is not necessarily monotonously increasing, but exhibits a non-trivial frequency dependence. This insight into crucial phenomena appearing during termination attempts provides a deeper understanding of the governing termination mechanisms in general, and therefore may open up the path towards an efficient termination of cardiac arrhythmia in the future.
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