Biodegradable magnesium alloys for orthopaedic applications

Area of Science:

• Biomaterials Science
• Orthopaedic Engineering
• Materials Science

Background:

• Magnesium (Mg)-based alloys are increasingly explored for biomedical applications, particularly in orthopaedics.
• Their inherent biodegradability eliminates the need for secondary implant removal surgery.
• Mg's abundance in the human body ensures excellent biocompatibility and a low elastic modulus, minimizing stress shielding.

Purpose of the Study:

• To review the evolution and current strategies for Mg-based orthopaedic implants.
• To discuss the challenges and future perspectives in developing Mg-based fracture fixation devices.

Main Methods:

• Literature review of Mg-based alloys for orthopaedic applications.
• Analysis of microstructure tailoring, alloy design, strengthening processes, and manufacturing techniques.
• Evaluation of bio-corrosion and mechanical performance trade-offs.

Main Results:

• Mg alloys offer a promising alternative to traditional implants due to biodegradability and biocompatibility.
• Rapid degradation and loss of mechanical integrity before bone healing are significant challenges.
• Microstructure control through alloy design and processing is crucial for optimizing performance.

Conclusions:

• Mg-based alloys hold significant potential for biodegradable orthopaedic implants.
• Further research is needed to optimize alloy design and processing for controlled degradation and mechanical stability.
• Tailoring microstructure is essential for successful Mg-based fracture fixation applications.