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Using gamification to enhance clinical trial start-up activities.

Karen Lane1, Ryan Majkowski1, Joshua Gruber1

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Gamification in clinical trials may speed up site activation and boost workforce engagement. This toolkit aims to improve trial efficiency and enjoyment during the crucial start-up phase.

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Area of Science:

  • Translational Science
  • Clinical Trial Management

Background:

  • The Trial Innovation Network (TIN), part of the National Center for Advancing Translational Science (NCATS) Clinical and Translational Science Awards (CTSA) Program, explores gamification to enhance clinical trial conduct.
  • The initiative aims to improve workforce engagement and operational efficiencies in clinical trials through innovative strategies.

Purpose of the Study:

  • To investigate the application of gamification within clinical trials to improve the engagement of the trial workforce.
  • To assess the impact of gamified elements on the efficiency of trial activities, particularly during the start-up phase.

Main Methods:

  • Existing electronic trial platforms were adapted to gamify tasks essential for meeting trial start-up timelines.
  • Scoreboards were developed using key performance indicators and familiar metrics to foster friendly competition.
  • Webinars were conducted to share and celebrate trial and game performance achievements.

Main Results:

  • Game scores showed a significant association with accelerated achievement of start-up milestones, including site activation, Institutional Review Board (IRB) submission, and IRB approval.
  • Findings suggest that gamification can increase the likelihood of faster site activation.
  • While game enjoyment and perceived pressure moderated performance in one trial, its effect was minimal in another.

Conclusions:

  • This retrospective analysis represents a novel exploration of gamification in clinical trials.
  • Preliminary results indicate that gamification may enhance performance and enjoyment during trial start-up.
  • Further research with larger sample sizes and robust statistical plans is needed to definitively isolate the effects of gamification on clinical trial outcomes.