Endovascular Treatment of Complex Intracranial Aneurysms With LEO+ Stents: The LEO II Cohort Study
Related Experiment Video
Updated: Sep 4, 2025
Biodegradable Magnesium Stent Treatment of Saccular Aneurysms in a Rat Model - Introduction of the Surgical Technique
Published on: October 1, 2017
Omer F Eker1, Olivier Levrier2, Emmanuel Houdart3
1Department of Neuroradiology, Hôpital Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France.
Insights
LEO+ stents effectively treat complex intracranial aneurysms, showing high occlusion rates and low morbidity. This study confirms their safety and efficacy in real-world use for aneurysm management.
Area of Science:
- Neurosurgery
- Interventional Neuroradiology
- Vascular Neurology
Background:
- Stent-assisted coiling is a key treatment for complex intracranial aneurysms.
- LEO+ stents are designed for challenging aneurysm anatomies.
Purpose of the Study:
- To evaluate the safety and efficacy of LEO+ stents for intracranial aneurysm treatment.
- To assess complete occlusion and complication rates at 18 months.
Main Methods:
- Prospective, observational, multicenter study with 176 patients.
- Inclusion of ruptured, unruptured, and recanalized aneurysms.
- 18-month follow-up for efficacy and safety endpoints.
Main Results:
- 89% complete/near-complete occlusion rate at 18 months.
- Low major recanalization rate of 1.8%.
- LEO+ stent-related mortality was 0.6% and morbidity was 4.1%.
Conclusions:
- LEO+ stents demonstrate high efficacy in achieving aneurysm occlusion.
- The study confirms the safety profile of LEO+ stents in complex cases.
- Real-world data supports LEO+ stent use for intracranial aneurysms.
Introduction:
Stent-assisted coiling is an established treatment option for intracranial aneurysms, particularly, wide neck aneurysms with complex anatomy. The purpose of the present study was to assess the safety and efficacy of LEO+ stents in the treatment of intracranial aneurysms.
Materials And Methods:
A prospective, observational, multicenter study including 12 centers was performed on patients with ruptured, unruptured, and recanalized intracranial aneurysms treated with LEO+ stents. The primary efficacy endpoint was the rate of complete aneurysmal occlusion at 18 months post-procedure, and the primary safety endpoint was the morbidity and mortality at 18 months post-procedure.
Results:
From March 2015 to June 2017, 176 patients were enrolled (mean age of 54.8 ± 11.5 years; 65.9% women). The aneurysms were located mainly in the anterior communicating artery (29.2%) and the middle cerebral artery (28.6%). They were mostly saccular (94%), with a mean dome size of 5.3 ± 2.6 mm and a mean aspect ratio of 1.2 ± 1.0. In total, 3% of the aneurysms were treated in the acute phase of rupture. Complete/nearly complete aneurysmal occlusion and major recanalization were observed in 89% (n = 146/164) and 1.8% (n = 3/164) of patients at 18-month follow-up, respectively. The LEO+ related mortality rate was 0.6% (n = 1/170), the morbidity rate was 4.1% (n = 7/170), and these patients were mRS 0-2 at 18 months.
Conclusion:
Our results reflecting the use of LEO+ stents in real-world conditions confirm the efficacy and safety of LEO+ stents in the management of complex intracranial aneurysms.
