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DNA Supramolecular Assembly on Micro/Nanointerfaces for Bioanalysis.

Chi Yao1, Junhan Ou1, Jianpu Tang1

  • 1Frontiers Science Center for Synthetic Biology, Key Laboratory of Systems Bioengineering (MOE), Institute of Biomolecular and Biomedical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, P. R. China.

Accounts of Chemical Research
|July 15, 2022
PubMed
Summary
This summary is machine-generated.

DNA supramolecular assembly on micro/nanointerfaces offers precise bioanalysis for precision medicine. This strategy enhances DNA

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Area of Science:

  • Materials Chemistry
  • Biomaterials Science
  • Nanotechnology

Background:

  • Precision medicine demands advanced bioanalytical tools with tailored molecular design and function.
  • Deoxyribonucleic acid (DNA), a sequence-programmable biomacromolecule, is a promising candidate for developing novel bioanalytical materials.
  • Current applications of DNA in bioanalysis include bioseparation, biosensing, and imaging, but enhanced precision is needed.

Purpose of the Study:

  • To explore DNA supramolecular assembly on micro/nanointerfaces for advanced bioanalysis.
  • To demonstrate the integration of DNA with microscale living cells and nanoscale particles for enhanced functionalities.
  • To showcase the potential of these DNA-based materials in advancing precision medicine.

Main Methods:

  • Utilizing rolling-circle amplification (RCA) to synthesize ultralong DNA strands for cell surface functionalization.
  • Designing DNA sequences with specific functional modules (e.g., aptamers) for targeted cell binding and separation.
  • Assembling DNA on nanoscale particles (e.g., UCNPs, AuNPs, MNPs) for applications in imaging, drug delivery, and cellular regulation.

Main Results:

  • Achieved efficient cell separation through DNA-functionalized microscale interfaces.
  • Demonstrated targeted tumor imaging and cellular regulation using DNA-assembled nanoscale particles.
  • Showcased controllable interfacial assembly processes and flexible regulation of bioanalytical material functions.

Conclusions:

  • DNA supramolecular assembly on micro/nanointerfaces is a powerful strategy for creating sophisticated bioanalytical materials.
  • This approach significantly enhances the precision and functionality of DNA-based bioanalysis.
  • The developed materials hold great promise for the advancement of precision medicine.