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Related Experiment Video

Updated: Sep 4, 2025

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice
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De-stressing plaques attenuates atherosclerosis progression.

Felix Sebastian Nettersheim1, Klaus Ley2

  • 1La Jolla Institute for Immunology, La Jolla, CA, USA; Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Trends in Immunology
|July 15, 2022
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Summary
This summary is machine-generated.

Immune cell aggregates called artery tertiary lymphoid organs (ATLOs) form in diseased arteries. New research shows ATLOs interact with the nervous system, impacting atherosclerosis progression.

Keywords:
ATLOatherosclerosisautonomous nervous systemsynapse

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Area of Science:

  • Cardiovascular Science
  • Immunology
  • Neuroscience

Background:

  • Atherosclerosis involves the formation of artery tertiary lymphoid organs (ATLOs) in diseased arteries.
  • The role of the nervous system in ATLO formation and function during atherogenesis is not well understood.

Purpose of the Study:

  • To investigate the interactions between ATLOs and the autonomous nervous system in the context of atherosclerosis.
  • To elucidate the implications of these interactions on the progression of atherosclerosis.

Main Methods:

  • Histological analysis of atherosclerotic arteries.
  • Immunohistochemistry to identify immune cells and nervous system components.
  • In situ hybridization to assess gene expression.

Main Results:

  • Distinct interactions were observed between ATLOs and autonomic nerve fibers within atherosclerotic lesions.
  • Specific molecular mediators involved in neuro-immune communication at the ATLO-nerve interface were identified.
  • Evidence suggests these interactions influence immune cell recruitment and inflammatory responses within ATLOs.

Conclusions:

  • The autonomous nervous system plays a significant role in modulating the immune microenvironment of ATLOs.
  • Targeting neuro-immune interactions within ATLOs may offer novel therapeutic strategies for atherosclerosis.