Troubleshooting Challenging Musculoskeletal Tumor Biopsies: Tricks of the Trade

Image-guided core needle biopsy of musculoskeletal lesions can be challenging due to a variety of technical, patient-related, and lesion-related factors. Poor preprocedural planning can result in low diagnostic yield, misdiagnosis, delay in care, and the need for additional procedures. Furthermore, suboptimal procedural technique may place the patient at an increased risk of iatrogenic complications. Optimizing pre-procedural planning by considering potential complications is important in ensuring a safe and successful procedure. We provide a review of strategies for troubleshooting challenging image-guided musculoskeletal tumor biopsies.