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Updated: Sep 4, 2025

Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins
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The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis

Mara De Marco Zompit1, Mònica Torres Esteban1, Clémence Mooser1

  • 1Department of Gynecology, University of Zurich and University Hospital Zurich, Schlieren, Switzerland.

Nature Communications
|July 16, 2022
PubMed
Summary

Cancer cells utilize a novel protein complex, CIP2A-TOPBP1, to manage DNA double-strand breaks (DSBs) during mitosis, ensuring genome stability. This discovery offers new insights into cancer cell repair mechanisms and potential therapeutic targets.

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