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Interference of layered double hydroxide nanoparticles with pathways for biomedical applications
Guoxin Jing1, Linnan Yang2, Hong Wang1
1Research Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shanghai, PR China.
Advanced Drug Delivery Reviews
|July 17, 2022
Summary
Layered double hydroxides (LDHs) show promise in nanomedicine due to their unique properties for controlled drug release and biological interactions. This review explores their potential in immune cell modulation, stem cell fate, and cancer therapy.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nanotechnology
Background:
- Layered double hydroxides (LDHs) are versatile inorganic materials with significant potential in biomedical applications.
- Their unique physicochemical properties, including pH-responsive controlled release and inherent biological effects, make them attractive for nanomedicine.
- LDH nanoplatforms offer advantages such as stability in circulation and targeted payload delivery.
Purpose of the Study:
- To comprehensively review the applications of LDH-based nanoparticles in nanomedicine.
- To elucidate the mechanisms by which LDHs interact with biological systems, including immune cells, stem cells, and tumor cells.
- To discuss the intracellular signaling pathways modulated by LDHs.
Main Methods:
- Literature review of recent advancements in LDH-based nanomedicine.
- Analysis of studies focusing on LDH nanoparticle interactions with biological pathways.
- Systematic exploration of intracellular signaling pathways affected by LDHs.
Main Results:
- LDHs demonstrate significant potential in modulating immune cell functions, guiding stem cell differentiation, and enhancing tumor treatments.
- LDH nanoplatforms act as "molecular switches" for controlled release of therapeutic agents.
- Specific cations within LDHs contribute to favorable biological effects and cellular regulation.
Conclusions:
- LDH-based nanomedicine presents a promising frontier with diverse therapeutic applications.
- Understanding the interplay between LDHs and intracellular signaling pathways is crucial for optimizing their efficacy.
- Further research and development are needed to overcome challenges for clinical translation of LDH nanomedicine.
