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Updated: Sep 4, 2025

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases
Published on: November 22, 2024
Thwarting protein synthesis leads to malaria parasite paralysis
Godfrey Mayoka1, John G Woodland2, Kelly Chibale2
1Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa; Department of Pharmacology and Pharmacognosy, School of Pharmacy, Jomo Kenyatta University of Agriculture and Technology, PO BOX 62000-00200, Nairobi, Kenya.
Abstract:
Inhibiting translation presents a tantalizing strategy to tackle the most virulent human malaria parasite. Xie et al. disclose a compound that binds selectively to Plasmodium falciparum tyrosine aminoacyl-tRNA synthetase, preventing the incorporation of tyrosine into nascent proteins and paving the way for a new generation of safe, effective antimalarials.
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